MY-ATRIA
Horizon 2020
Ruolo DEIB: Coordinatore
Data inizio: 01/11/2017
Durata: 48 mesi
Sommario
MY-ATRIA is a multidisciplinary network which develops research and training “without walls” among academic, industrial and clinical entities in the area of atrial disease.
It will generate a new profile of Researcher with an intersectoral expertise able to fill the existing gap between basic research and clinical/business-oriented solutions.
MY-ATRIA brings together universities, companies and hospitals from 5 European countries (Italy, Spain, Sweden, Netherlands and Germany).
The aim of MY-ATRIA is to train a new figure of modern professional researchers in Atrial Fibrillation field with multidisciplinary competencies, able to transfer advances in basic science to market and clinics.
Three main research lines are investigated:
- Understanding atrial arrhythmia mechanisms: a better interpretation of atrial arrhythmias mechanisms will be obtained by studying the electrocardiogram (ECG), and intra-cavity atrial electrogram (EGM) using a hybrid in-silico/in-vivo methodology. Abnormal interatrial connections, normal and dilated left atrium, electrical remodelling, coupling, and fibrosis will be the target of this research activity.
- AF Monitoring, progression and risk stratification: a set of new tools will be developed to analyse and characterize the progression of paroxysmal AF suitable for implementation in wearable devices, to detect and monitor AF effectively in large populations for screening purposes. Moreover, multi-parametric AF detectors that include information from other available sensors (wristband, non-contact electrodes among others) will be developed.
- Studying the effects of treatment: by developing computational models and linking them to ECG and EGM. Electrocardiographic markers of the AF process will be assessed and linked to the treatment outcome in different patient categories and subtypes of AF including new-onset AF, structural heart disease.
Risultati del progetto ed eventuali pubblicazioni scientifiche/brevetti
Dissemination material and public deliverables are available in the following attachments:
Events
Publications
ESR 1 – Jordan Elliott
ESR 3 – Giorgio Luongo
ESR 4 – Muhamed Vila *
ESR 9 – Guadalupe García Isla
ESR 10 – Luca Azzolin
ESR 11 – Chiara Celotto
ESR 12 – Jennifer Riccio
Deliverables
Events
- MY-ATRIA Introductory Event, Politecnico di Milano, Milano, Italy, 22-23 October, 2018.
- Winter School on “Arrhythmic substrate in the human atria: histology, structure and function”, Lund, Sweden 15-17 January, 2019
- Summer School on “Modeling and Signal Processing”, Jaca, Spain, 22-25 September, 2019
Publications
ESR 1 – Jordan Elliott
- Jordan Elliott, Olaf Doessel, Axel Loewe, Luca Mainardi, Valentina Corino, Josè Felix Rodriguez Matas. “An In-Silico Study of the Effects of Conductance Variation on the Regionally Based Action Potential Morphology.”, Computing in Cardiology, Sept 2019, Singapore, Singapore
ESR 3 – Giorgio Luongo
- Luongo G, Schuler S, Rivolta MW, Dössel O, Sassi R, Loewe A, "Automatic Classification of 20 Different Types of Atrial Flutter Using 12-Lead ECG Signals: a Preliminary Computational Study", Atrial Signals Conference, Bordeaux, Spain, Oct., 2019.
- Luongo G, Schuler S, Dössel O, Loewe A, "12-Lead ECG Feature Identification to Discriminate Different Types of Atrial Flutter", EMBC, Berlin, Germany, Jul., 2019.
- Luongo G, Schuler S, Almeida TP, Soriano DC, Dössel O, Loewe A, "Discrimination od Atrial Flutter on Simulated 12-Lead-ECG Signals by Applying Biosignal Processing", Gordon Research Conference - Cardiac Arrhythmia Mechanisms, Lucca, Italy, Mar.-Apr., 2019.
ESR 4 – Muhamed Vila *
- Massimo W. Rivolta, Roberto Sassi, Muhamed Vila, “Refined Ventricular Activity Cancellation in Electrograms During Atrial Fibrillation by Combining Average Beat Subtraction and Interpolation”, EMBC 2019.
- Muhamed Vila, Massimo W. Rivolta, Federico Lombardi, Roberto Sassi, “The Use of Acceleration and Deceleration Capacities on Localized Atrial Period Series to Distinguish SR and AF with Administration of Isoproterenol”, Atrial Signals 2019
- J Saiz-Vivo, M de Melis “Assessment of the AF triggers and their role in its progression” Medtronic Science and Technology European Conference, June 2019, Maastricht, Netherlands.
- J Saiz-Vivo, VDA Corino, MW Rivolta, R Sassi, LT Mainardi “Assessment of the effect of fibrillatory waves in the analysis of spatial heterogeneity of ventricular repolarization” Computing in Cardiology, Sept 2019, Singapore, Singapore.
- J Saiz-Vivo, M de Melis “Assessment of the AF triggers and their role in its progression” Medtronic Science and Technology US Conference, Oct 2019, Minneapolis, Minnesota.
ESR 9 – Guadalupe García Isla
- García-Isla G, Corino VDA, Mainardi L, "Cardiac Tachyarrhythmia Detection by Poincaré Plot-based Image Analysis", Computing in Cardiology Conference, Singapore, Sept., 2019.
ESR 10 – Luca Azzolin
- Azzolin L., Sanchez J., Schuler S., Wachter A., O. Doessel, A. Loewe, “Initiation and mainteinance of re-entrant cardiac propagation: a computational vulnerability study”, EMBC, Berlin, July, 2019.
- Azzolin L., O. Doessel, A. Loewe, “Influence of the protocol used to induce arrhythmia on atrial fibrillation vulnerability”, EMBC, Berlin, July, 2019.
ESR 11 – Chiara Celotto
- Celotto C, Sánchez C, Laguna P, Pueyo E, “Small-Conductance Calcium Activated Potassium Current Inhibition in Autonomically Stimulated Human Atrial Myocytes: a Computational Investigation” Computing in Cardiology Conference, Singapore, Sept., 2019.
ESR 12 – Jennifer Riccio
- Riccio J, Alcaine A, de Groot N, Houben R, Laguna P, Martínez J P, “Characterization of Propagation Patterns with Omnipolar EGM in Epicardial Multi-Electrode Arrays”, Computing in Cardiology Conference, Singapore, Sept., 2019.
Deliverables