- CELLS - Circular Economy Lab for Life Sciences
- CFDHub@Polimi - Laboratorio di fluidodinamica computazionale
- CIRC eV - Circular Factory for the Electrified Vehicles of the Future
- Climate-Lab
- CREA Lab - Laboratory of Compressible-Fluid Dynamics for Renewable Energy Applications
- DataCloud - Cloud, Data Science, Big Data
- ED-ME Lab - Laboratory for Environmental Design and Multisensory Experiences
- E4Sport - Engineering for Sport Laboratory
- GEOLab - Laboratorio di Geomatica e Osservazione della Terra
- High Strane Rate Lab
- I.DRIVE - Interaction between Driver Road-Infrastructure Vehicles and Environment
- Internet of Things Lab
- Laboratorio di Modellazione Molecolare
- LAFOS - Laboratory on Fiber Optic Sensors
- LuCId Lab - Live Cell Imaging
- MetaMAT-Lab
- MEMS&3D-LAB
- NanoMedLab - Laboratory of Nanomedicine
- PHEEL - PHysiology, Emotion and Experience Laboratory
- PoliNDT - Laboratorio per la Diagnostica e il Monitoraggio Strutturale
- PSVL - PoliMi Sound and Vibration Laboratory
- SoLINano-Σ Lab - Solid-Liquid Interface Nanomicroscopy and Spectroscopy Lab
- Urbanscope Lab
- WE-COBOT LAB - Wearable and Collaborative Robotics Lab
