Andrea Castoldi received the M.Sc. degree in Electronic Engineering from Politecnico di Milano in 1989 and the Ph.D. degree in 1993. In 1993 Assistant Professor at Universita’ degli Studi di Milano, Dip. Fisica, and in 1998 Associate Professor at Politecnico di Milano, Dip. Ingegneria Nucleare. Since 2005 he has been Full Professor of Electronics at Politecnico di Milano, Dip. Elettronica Informazione e Bioingegneria. In 1992-93 he was visiting scientist at Brookhaven National Laboratory, Instrumentation Division (USA) where he contributed to the development of novel silicon drift detectors and integrated front-end electronics on high resistivity silicon for particle tracking and for high resolution X-ray spectroscopy.
His research interests are in the field of radiation detectors for scientific applications, low-noise readout electronics and signal processing techniques, in the simulation and characterization of semiconductor devices. He is co-inventor of a novel semiconductor detector for spectroscopic imaging of X-rays. He is author of more than 180 peer-reviewed publications and holds 1 national patent and 2 international patents.
Since 1990 associated to INFN with a research appointment and member of the IEEE.
Since 1997 he has been Head of the Imaging Detectors and Low-Noise Electronics Lab of Politecnico di Milano. Member of the Organizing committee of the X and of the XI European Symposium on Semiconductor Detectors and Member of the International Advisory Committee of ANSiP 2011 – Advanced School and Workshop on Nuclear Physics Signal Processing. He served as Reviewer and Topic Convener for several editions of the IEEE Nuclear Science Symposium and Medical Imaging Conference. He has been principal investigator of several projects funded by MIUR, INFN, ASI and of international research contracts. He coordinated several beam-times at Sincrotrone ELETTRA Trieste, Diamond (UK), LABEC Firenze, Laboratori Nazionali del Sud, DESY Petra III, European XFEL. 
He recently participated in the successful development of the novel telescope array FARCOS (Femtoscope ARray for Correlation and Spectroscopy) and in the development of the DSSC detector, an ultra- fast X-ray 2D imaging detector specifically designed for low-energy X-ray imaging experiments (0.5-6 keV) currently installed at the European XFEL facility in Hamburg.