Luca Mottola was appointed by the Steering Committee of CPS-IoT WEEK as the General Chair of the 2022 edition, to be held in Milano. CPS-IoT Week is the flagship event on Cyber-Physical Systems and Internet-of-Things research. It brings together five top conferences, HSCC, ICCPS, IPSN, RTAS and IoTDI, multiple workshops, tutorials, competitions and various exhibitions from both industry and academia. After two editions the pandemic forced to be in virtual format, the community is eager to return to an in-person event in Milano.